1721年ボストン天然痘流行の死亡率は自然感染約15% 接種患者2%未満か
Question asked:
“1721年のボストンでの天然痘流行において、自然感染した市民の死亡率は約15％で、接種を受けた患者の死亡率は2％未満であった。”
Summary
In the 1721 Boston smallpox epidemic, the fatality rate among those who contracted the disease naturally was about 14‑15 %, while the mortality among inoculated patients was around 2 % or less. These figures are consistently reported across several historical sources.
Sources 60 searched
- The Tercentenary of the Boston Smallpox Epidemic of 1721
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- The Last Smallpox Epidemic in Boston and the Vaccination Controversy, 1901–1903 | New England Journal of Medicine
Among 754 patients with smallpox who had evidence of vaccination (Figure 2), there were 82 deaths (case fatality rate, 11 percent), whereas among 842 unvaccinated patients, there were 188 deaths (case fatality rate, 22 percent).
- The Smallpox Epidemics in America in the 1700s and ... - PMC
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- Edward Jenner and the history of smallpox and vaccination - PMC
The fatality rate for the naturally contracted disease was 14%, whereas Boylston and Mather reported a mortality rate of only 2% among variolated individuals (12). This may have been the first time that comparative analysis was used to evaluate a medical procedure.
- Smallpox, Inoculation, and the Revolutionary War (U.S. National Park Service)
Boylston noted that during the epidemic of 1721, the estimated fatality rate of those who naturally contracted smallpox was 14%, while the fatality rate of the inoculated was only 2%. Though many Bostonians feared and distrusted the procedure ...
- SCIENTIFIC BACKGROUND ON SMALLPOX AND ... - NCBI
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- The Boston Smallpox Epidemic, 1721 | Contagion - CURIOSity Digital Exhibits
Between April and December 1721, 5,889 Bostonians had smallpox, and 844 died of it. October was the worst month, with 411 deaths.
- Pandemic Perspectives - CDN
City of Boston, c. 1721
- The Fight against Smallpox from Inoculation to Vaccination
In her article on the smallpox ... approximately 287 people were inoculated, only six of whom died, contrasted with a 14 percent mortality rate among the general population....
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