Tetanus vaccine stimulates antibodies against toxin – True
Question asked:
“A tetanus vaccine works by stimulating the immune system to produce antibodies against the tetanus toxin produced by Clostridium tetani.”
Summary
The tetanus vaccine contains an inactivated form of the tetanus toxin (toxoid) that prompts the immune system to generate neutralizing antibodies. These antibodies bind to the toxin, preventing it from affecting nerve cells and providing protection against tetanus. This mechanism is well‑established in medical literature.
Sources 60 searched
- Tetanus vaccine-induced human neutralizing antibodies provide full protection against neurotoxin challenge in mice - ScienceDirect
The TL–HN fragment, as a protective antigen, induced the highest levels of neutralizing antibodies, indicating that it might contain some crucial epitopes. Further experiments revealed that the protective effect of TL-HN was superior to that ...
- Tetanus Toxoid - an overview | ScienceDirect Topics
Because the disease is caused solely ... prevented by vaccination with tetanus toxoid, an inactivated form of the neurotoxin that induces the production of neutralizing antibodies....
- Tetanus Antibody - an overview | ScienceDirect Topics
It is recommended that this vaccine ... injection for routine prophylaxis, after being injured. The antibodies directed against the toxin have a higher affinity for the toxin than do the toxin receptors on nerve cells....
- Chapter 21: Tetanus | Pink Book | CDC
In 1889, Kitasato Shibasaburo isolated the organism from a human, showed that it produced disease when injected into animals, and reported that the toxin could be neutralized by specific antibodies. In 1897, Edmond Nocard demonstrated the protective effect of passively transferred antitoxin, ...
- Characterization of neutralizing chimeric heavy-chain antibodies against tetanus toxin - PMC
TeNT-Hc can bind to cell receptors in a nontoxic form and induce protective antibodies in animals, making it a potential candidate subunit vaccine to replace tetanus toxoid vaccines.23–25 TeNT-Hc is a protective antigen, and immunization with TeNT-Hc alone can achieve immunity similar to ...
- Tetanus Toxoid - StatPearls - NCBI Bookshelf - NIH
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- Diphtheria and Tetanus Toxoids - NCBI - NIH
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