Are Statins Necessary for At-Risk Patients
“Are statins necessary”
Summary
Statin therapy is widely endorsed for primary and secondary prevention of cardiovascular disease, substantially lowering the risk of heart attacks, strokes, and related mortality in individuals with elevated risk or existing disease. In healthy, low‑risk people, the benefit is minimal and not clearly demonstrated, so statins are not universally required for everyone.
Sources 59 searched
- Statins don't reduce cardiovascular disease risk in healthy ...
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- Role of Statins in Coronary Artery Disease - PMC - NIH
Nowadays, statin therapy is widely recommended for the primary and secondary prevention of cardiovascular disease in a wide range of people (Table 1). The benefits of statin therapy are attributed to pleiotropic effects that are independent of a lowering of the LDL-cholesterol level.
- Potential Benefits and Risks Associated with the Use of Statins
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- How do statins prevent heart attacks and strokes?
Statins save lives and prevent heart attacks and strokes.
- Assessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials - The Lancet
The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials · Lancet. 2012; 380:581-590 ... Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials
- Rosuvastatin - StatPearls - NCBI Bookshelf - NIH
Off-label uses include noncardioembolic ... in acute ischemic stroke.[7] According to results from a meta-analysis, statin therapy significantly reduces mortality in heart transplant recipients and decreases the incidence of fatal rejection and coronary vasculopath...
- Identifying optimal primary prevention interventions for major cardiovascular disease events and all-cause mortality: a systematic review and hierarchical network meta-analysis of RCTs - NCBI Bookshelf
Blood pressure-lowering medications (risk ratio 0.82, 95% confidence interval 0.71 to 0.94), tight blood pressure control (risk ratio 0.66, 95% confidence interval 0.46 to 0.96), statins (risk ratio 0.81, 95% confidence interval 0.71 to 0.91) and multifactorial lifestyle interventions (risk ...
- Statin wars: have we been misled about the evidence? A ...
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