Neural Therapy for Movement Disorders: No Proven Benefit Found
“Can neural therapy reduce movement disorders like distonia or diskinesia?”
Summary
Current scientific literature does not support neural therapy as an effective treatment for dystonia or dyskinesia. Evidence‑based interventions for these movement disorders include deep brain stimulation, non‑invasive brain stimulation, botulinum toxin injections, and targeted rehabilitation, but neural therapy lacks demonstrated clinical efficacy.
Sources 56 searched
- Noninvasive brain stimulation for Parkinson’s disease and dystonia - PMC
Studies of rTMS or tDCS in dystonia have provided abundant data on physiology, but few on clinical effects. Multiple mechanisms likely contribute to the clinical effects of rTMS and tDCS in movement disorders, including normalization of cortical excitability, rebalancing of distributed neural network activity, and induction of dopamine release.
- Editorial: Advances in Invasive and Non-invasive Brain Stimulation for Dystonia and Other Hyperkinetic Movement Disorders - PMC
With contacts extending from the superior cerebellar peduncle to the dentate nuclei an almost complete resolution of symptoms was achieved with deep cerebellar stimulation highlighting its potential as a treatment for both tremor and dystonia. Fu et al. similarly expands the neuroanatomical ...
- Treatment of Dystonia: Medications, Neurotoxins, Neuromodulation, and Rehabilitation - PMC
Dystonia is a heterogeneous disorder with many etiologies, varied clinical presentations, and diverse treatment responses. Despite the considerable progress in our understanding of this condition, disease-modifying therapies do not exist for most dystonia types.
- Update on Deep Brain Stimulation for Dyskinesia and Dystonia: A Literature Review - PubMed
Dystonia and Cerebellum: From Bench to Bedside. Morigaki R, Miyamoto R, Matsuda T, Miyake K, Yamamoto N, Takagi Y. Morigaki R, et al. Life (Basel). 2021 Jul 31;11(8):776. doi: 10.3390/life11080776. Life (Basel). 2021. PMID: 34440520 Free PMC article. Review. Deep brain stimulation (DBS) in movement disorders management: exploring therapeutic efficacy, neurobiological mechanisms, and clinical implications.
- Non-invasive brain stimulation and kinesiotherapy for treatment of focal dystonia: Instrumental analysis of three cases - ScienceDirect
NIBS associated with kinesiotherapy produced a long-term improvement of dystonia symptoms in all three patients. rTMS and tDCS associated with kinesiotherapy showed to be useful and safe to relief the dystonia symptoms in individuals with different ...
- Role of deep brain stimulation in the treatment of secondary dystonia–dyskinesia syndromes - ScienceDirect
Electrical neuromodulation of subcortical structures may be effective in selected cases of mixed dystonia–dyskinesia syndrome. Clinical and radiological selection criteria should be strictly analyzed in order to confirm relative preservation ...
- Treatment of Dystonia: Medications, Neurotoxins, Neuromodulation, and Rehabilitation - ScienceDirect
As a general principle, BoNT injections have the benefit of being highly targeted therapies, potentially avoiding unwanted systemic effects which may be more common concerns with oral drugs. While multiple class I trials have been conducted in cervical dystonia (CD), the literature for BoNT treatment of other forms of dystonia such as oromandibular dystonia and laryngeal dystonia largely consists of open-label series and uncontrolled trials. There is a high level of evidence for the efficacy of BoNT in the treatment of CD, with class I trials demonstrating benefit in all four commercially available formulations in the USA (onabotulinumtoxinA, incobotulinumtoxinA, abobotulinumtoxinA, and rimabotulinumtoxinB), all of which have FDA approval for use in CD.
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