Does CB1 Really Promote Weight Gain
“CB1 weight gain”
Summary
Activation of CB1 receptors stimulates appetite and fatty‑acid synthesis, leading to weight gain and obesity in animal studies and humans. Blocking CB1, either centrally or peripherally, reduces food intake and prevents or reverses weight gain.
Sources 56 searched
- Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity - PMC
Endogenous cannabinoids acting at CB1 receptors stimulate appetite, and CB1 antagonists show promise in the treatment of obesity. CB1–/– mice are resistant to diet-induced obesity even though their caloric intake is similar to that of wild-type mice, suggesting that endocannabinoids also ...
- The Peripheral Cannabinoid Receptor Type 1 (CB1) as a Molecular Target for Modulating Body Weight in Man - PMC
The cannabinoid 1 (CB1) receptor regulates appetite and body weight; however, unwanted central side effects of both agonists (in wasting disorders) or antagonists (in obesity and diabetes) have limited their therapeutic utility. At the peripheral level, CB1 receptor activation impacts the energy ...
- CB1 Antagonism Exerts Specific Molecular Effects on Visceral and Subcutaneous Fat and Reverses Liver Steatosis in Diet-Induced Obese Mice - PMC
Recently, evidence has accumulated ... enzyme proteins catalyzing the endocannabinoid formation and degradation (3). Activation of central CB1 receptors clearly promotes food intake and weight gain (4–6)....
- Recent progress in the pharmacotherapy for obesity - ScienceDirect
INV-202, a next-generation CB1-R ... an average weight reduction of 3.5 kg while the placebo-group participants having an average weight gain of 0.55 kg (p < 0.01), supporting its role in establishing a negative energy balance ...
- Weight regain after cessation of GLP-1 drugs | The BMJ
Sun Q. Weight regain after cessation of GLP-1 drugs BMJ 2026; 392 :r2586 doi:10.1136/bmj.r2586
- Trajectory of weight regain after cessation of GLP-1 receptor agonists: a systematic review and nonlinear meta-regression - eClinicalMedicine
GLP-1RA cessation is associated with a predictable and decelerating pattern of weight regain, which appears to plateau below pre-treatment levels, suggesting that partial weight-loss benefit may persist long-term but is substantially attenuated.
- Caloric restriction, physical exercise, and CB1 receptor blockade as an efficient combined strategy for bodyweight control and cardiometabolic status improvement in male rats | Scientific Reports
Lost weight maintenance further improved the glycemic profile of the animals after the combined action of physical exercise and AM251 administration, enhancing metabolic activities that promote insulin sensitivity. The CB1 receptor is highly expressed in central and peripheral nervous system, as well as various peripheral tissues30,31. Evidence suggests that endocannabinoids are directly involved in the control of food intake and energy utilization by targeting these central and peripheral sites, including skeletal muscle, liver, and adipose tissue32.
- A neutral CB1 receptor antagonist reduces weight gain in rat - PubMed
Cannabinoid (CB)1 receptor inverse agonists inhibit food intake in animals and humans but also potentiate emesis. It is not clear whether these effects result from inverse agonist properties or from the blockade of endogenous cannabinoid signaling. Here, we examine the effect of a neutral CB1 antagonist, AM4113, on food intake, weight gain, and emesis.
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