Chromhidrosis is a rare condition causing pigmented sweat

In 1954 Walter Shelley and Harry Hurley determined that lipofuscin granules are responsible for the pigmentation of the sweat seen in apocrine chromhidrosis. Lipofuscin is a yellow-brown pigment that is usually found in the cytoplasm of cells of various organs and is not specific to apocrine ...

Identification of extensive lipofuscin granules in apocrine glands helps differentiate the etiologic process from toxin-induced pseudochromhidrosis and extrinsic pigment–induced eccrine chromhidrosis.[35] The role of lipofuscin in most other pathologies remains poorly defined. The correlation between age-related macular degeneration and lipofuscin accumulation has been hypothesized but remains highly controversial.

Primarily after emotional stress patients complain of coloured sweat secretion (black, green, blue or yellow). The deposition of lipofuscin in the apocrine glands may be the cause of this disease, the different colours of swea …

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Apocrine chromhidrosis is often because of oxidation of lipofuscin, and an increased number of yellow-brown lipofuscin granules in the apocrine glands is observed on Wood’s lamp examination.2 An eccrine source was also considered, since ingestion ...

The histology of the skin biopsy taken from the axilla was non-specific, providing no evidence of pseudochromhidrosis and revealing no lipofuscin granules in the apocrine glands. In the absence of an aetiology, further questioning, particularly about the patient's dietary habits, revealed an excessive consumption of a pink energy drink, which had been consumed daily for months. The diagnosis of eccrine chromhidrosis due to food colouring was therefore considered.

... Apocrine chromhidrosis is rare. It usually starts after puberty once the apocrine glands have matured, but has also been reported in infants. Chromhidrosis occurs in both sexes. Apocrine chromhidrosis is due to lipofuscin granules in the apocrine sweat glands.

It is caused by the deposition of lipofuscin in the sweat glands. Cases of red, blue, green, yellow, pink, and black sweat have been reported. Usually, chromhidrosis affects the apocrine glands, mainly on the face and underarms. A limited number of treatment options exist, including regular application of capsaicin cream, and prolonged relief may be provided by botulinum toxin treatment. Chromogenic pigments ...