Shingrix vaccine may lower Alzheimers risk, study suggests
“Does shingrix vaccine reduce risk of Alzheimer”
Summary
Recent large‑scale studies using natural‑experiment designs find that the recombinant shingles vaccine (Shingrix) is linked to a markedly lower incidence of dementia, including Alzheimer’s disease, over multiple years of follow‑up. The evidence points to a probable protective effect, though definitive proof of causality remains pending.
Sources 59 searched
- The recombinant shingles vaccine is associated with lower risk of dementia | Nature Medicine
A natural experiment including more than 200,000 people who received a shingles vaccine reveals that, within 6 years of vaccination, the recombinant vaccine is associated with lower risk of dementia than is the live vaccine.
- A natural experiment on the effect of herpes zoster vaccination on dementia | Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of 7 years by approximately one-fifth.
- Recombinant zoster vaccine is associated with a reduced risk of dementia | Nature Communications
The study shows that vaccination with two doses of recombinant zoster vaccine is associated with a 51% reduction in the risk of dementia in adults aged ≥65 years. Reduction in risk is comparable across subgroups and remains statistically ...
- Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections - PMC
Understanding the relative ... of Alzheimer’s disease and other neurodegenerative disorders. Here, we analysed EHR data to test the possibility that AS01 contributes to the reduction in risk of dementia seen with Shingrix by also investigating the effect of the AS01-containing RSV vaccine ...
- The effect of shingles vaccination at different stages of the dementia disease course: Cell
We also examined only those dementia diagnoses that were made subsequent to an MCI diagnosis during the follow-up period. As shown in Table S2, the relative reductions in dementia incidence from HZ vaccination receipt and eligibility were generally largest for diagnoses of mixed dementia as opposed to diagnoses of Alzheimer’s disease and diagnoses of vascular dementia.
- Herpes zoster vaccination and incident dementia in Canada: an analysis of natural experiments - The Lancet Neurology
After the start of the programme, new dementia diagnoses among the birth cohorts eligible for herpes zoster vaccination in Ontario were significantly less common than in the same birth cohorts in other Canadian provinces that did not have a herpes zoster vaccination programme. This analysis of natural experiments provides evidence, which is more likely to reflect a causal relationship than previous evidence from more standard observational data analyses, that herpes zoster vaccination prevents or delays incident dementia. Mechanistic research into this effect could provide insights into the pathophysiology of dementia and maintenance of neuroimmune health in older age.
- For those living with dementia, new study suggests shingles vaccine could slow the disease
A new analysis of a vaccination program in Wales found that the shingles vaccine not only appeared to lower new dementia diagnoses by 20%, it also helped those who already have the disease.
- Link between shingles vaccine and slowed dementia is ‘promising,’ says expert | Harvard T.H. Chan School of Public Health
All in all, he said, the study ... effective treatments. “Obviously, the [shingles] vaccine was not designed or optimized to prevent dementia, so this is sort of an incidental finding,” Ascherio said....
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