CIBA Team Successfully Isolated Reserpine from Rauvolfia serpentina in 1952
“In 1952, a Swiss research team led by Johannes M. Müller and Emil Schlittler at CIBA successfully isolated the active principle in a pure, crystalline state from Rauvolfia serpentina, naming the novel alkaloid "reserpine".”
Summary
In 1952, a Swiss team at CIBA, including Johannes M. Müller, Emil Schlittler and H.J. Bein, isolated the active principle from Rauvolfia serpentina in a pure, crystalline form and named the alkaloid reserpine. The isolation and naming were reported in the first complete 1952 publication on its chemistry and pharmacology.
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- Indian Rauwolfia research led to the evolution of neuropsychopharmacology & the 2000 Nobel Prize (Part II) - PMC
A paper by Vakil36 from Bombay ... in Switzerland published the first complete report on chemistry and pharmacology of reserpine which was isolated in 1952 and introduced as the drug Serpasil38....
- Rauwolfia in the Treatment of Hypertension - PMC - NIH
In 1952, CIBA Labs (now Novartis) in Switzerland published the first complete report on the chemistry and pharmacology of reserpine.7 Also in 1952, isolated reserpine was introduced as the drug Serpasil for the treatment of hypertension, tachycardia, and thyrotoxicosis.7
- Global Pharma and Local Science: The Untold Tale of Reserpine - PMC
Reserpine, an alkaloid derived ... is almost forgotten. Following its isolation “in pure crystalline form” from the roots of the Rauwolfia plant in 1952 by Műller, Schlittler, and Bein, under the Aegis of the Swiss Pharmaceutical Companies CIBA ......
- Mechanism of Hypotensive Action of Reserpine, an Alkaloid of Rauwolfia serpentina | Nature
Müller, J. M., Schlittler, E., and Bein, H. J., Experientia, 8, 338 (1952).
- Reserpine Derivatives with Specific Hypotensive or Sedative Activity | Nature
RECENTLY it has been reported, by Ciba Laboratories1,2, that two reserpine analogues show more specific effects than reserpine. Methyl-18-O(3-NN-dimethylaminobenzoyl)reserpate (or SU 5171) exhibits sedative activity, while carbethoxysyringoyl-methylreserpate (syrosingopine or SU 3118) is effective ...
- References - Biologic Markers in Reproductive Toxicology - NCBI Bookshelf
Budnick, I.S., S.Leikin, and L.E.Hoeck. 1955. Effect in the newborn infant of reserpine administered antepartum. A.M.A. Am. J. Dis. Child. 90:286–289.
- [Historical approach to reserpine discovery and its introduction in psychiatry] - PubMed
In the present article, a revision is made of the complicated process leading to the isolation and synthesis of reserpine, by the Swiss pharmaceutical company Ciba (Schlittler and Müller) and how its pharmacological properties (Bein) were discovered and studied, in the animals laboratory, mainly, the "tranquillizers".
- Reserpine — Grokipedia
Reserpine was isolated in 1952 ... serpentina plant roots, where it was identified as the primary active sedative alkaloid responsible for the plant's tranquilizing properties.[2] ......
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