Is it true that acetamipride has no proven impact on huma...
“Is it true that acetamipride has no proven impact on human health?”
Summary
While acetamiprid is generally considered low‑hazard under normal exposure, documented cases of acute poisoning—including severe toxicity and a fatality—demonstrate that it can affect human health. Regulatory assessments also note moderate oral toxicity and classify it as an unlikely human carcinogen, indicating proven health impacts at sufficient doses.
Sources 55 searched
- Acetamiprid - an overview | ScienceDirect Topics
Currently, acetamiprid has not ... acetamiprid accumulation in the body. Overall, the general belief is that acetamiprid presents low hazard risks to human/vertebrate populations under normal conditions....
- A fatal case of acetamiprid poisoning with turquoise urine - ScienceDirect
Acetamiprid is a member of neonicotinoid insecticides with a low risk of toxicity in humans. However, ingestion of large amounts may cause severe poisoning. This is the first case reported in the literature in which severe toxicity and death ...
- Single and joint toxicity assessment of acetamiprid and thiamethoxam neonicotinoids pesticides on biochemical indices and antioxidant enzyme activities of a freshwater fish Catla catla - ScienceDirect
However, a few authors have reported the toxicity of acetamiprid and thiamethoxam in single or combined exposures to aquatic animals (Yan et al., 2016; Hano et al., 2017; Bartlett et al., 2019; Ma et al., 2019; Butcherine et al., 2021). In aquatic toxicology studies, biochemical parameters are commonly employed to evaluate the toxicity of pesticides.
- Two cases of acute poisoning with acetamiprid in humans - PubMed
Despite wide usage, human exposure resulting in toxicity is quite limited, and this is the first report in the English literature about acute acetamiprid poisoning in humans.
- United States Office of Prevention, Pesticides Environmental Protection
Acetamiprid pesticide has been classified as a “unlikely” human carcinogen. ... FQPA safety factor =1). The lowest acute aggregate exposure DWLOC is 600 ppb (children 1-6 years) and is greater than ... The lowest short- and intermediate-term DWLOC is 400 ppb for multiple population subgroups.
- Statement on the active substance acetamiprid - PMC
According to the EFSA conclusion, acetamiprid was proposed to be classified as carcinogenic category 2 but not as toxic for reproduction category 2, in accordance with the provisions of Regulation (EC) No 1272/2008. Conditions concerning human health for the consideration of endocrine disrupting ...
- Acute poisoning with acetamiprid: a case report - PMC
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- Statement on the toxicological properties and maximum residue levels of acetamiprid and its metabolites - PMC
Regarding the human studies, one study reported only internal concentrations (no health effects were measured; Table 4 ) and two studies evaluated possible associations between internal exposure data and (health) effects (Table 5 ). These studies were subdivided, because they followed different RoB assessment methods. Heatmap results of the RoB for the endpoints measured in the new in vivo studies notified by PAN Europe in the extension of the mandate for acetamiprid.
- Acetamiprid Human Health Risk Assessment DP Barcode D449925 1 of 46
Acute lethality studies conducted with acetamiprid indicate it is moderately toxic via the acute · oral route (Category II); however, it has lower toxicity via the acute dermal or inhalation routes · (Categories III). It is non-irritating to the eyes and skin and is not a dermal sensitizer.
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