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DNA Base Pairing: Does A Always Pair with T and C with G?

“With dna does a always pair with t and c always pairs with g”
True
Confidence: High Checked on May 27, 2026

Summary

In double‑stranded DNA, adenine (A) always pairs with thymine (T) and cytosine (C) always pairs with guanine (G) through complementary hydrogen bonding. This rule holds universally for DNA molecules.

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Sources 59 searched

genome.gov
  • Base Pair

    The two strands are held together by hydrogen bonds between pairs of bases: adenine pairs with thymine, and cytosine pairs with guanine. One copy of the human genome consists of approximately 3 billion base pairs of DNA, which are distributed ...

  • Adenine

    Adenine (A) is one of the four nucleotide bases in DNA, with the other three being cytosine (C), guanine (G) and thymine (T). Within a double-stranded DNA molecule, adenine bases on one strand pair with thymine bases on the opposite strand.

cancer.gov
sciencedirect.com
genomicseducation.hee.nhs.uk
  • Base pairs - Genomics Education Programme

    A unit of two bases in a molecule of DNA or RNA. In DNA, adenine always pairs with thymine (A-T), and guanine always pairs with cytosine (G-C). RNA is the same, except that adenine always pairs with uracil (A-U).

passel2.unl.edu
  • DNA Structure | DNA and DNA Extraction - passel

    There are only 4 nucleotides in DNA, Adenine (A), Guanine (G), Thymine (T), and Cystosine (C). The chemical structures of Thymine and Cytosine are smaller, while those of Adenine and Guanine are larger. Size and structure of the specific nucleotides cause Adenine and Thymine to always pair together while Cytosine and Guanine always pair together.

bbc.co.uk
bio.libretexts.org
  • 5.4: Base Pairing in DNA and RNA - Biology LibreTexts

    The rules of base pairing explain the phenomenon that whatever the amount of adenine (A) in the DNA of an organism, the amount of thymine (T) is the same (called Chargaff's rule). Similarly, whatever the amount of guanine (G), the amount of cytosine (C) is the same.

labxchange.org

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